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Anti-EBV (Zebra) IgM

《Specification 》:

Article Number: ORG 910

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Features & Function

 

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Anti-EBV (ZEBRA) IgM is used for the quantitative determination of human IgM antibodies against certain peptide sequences in the ZEBRA protein (BZLF-1) of the Epstein-Barr virus. The detection of these IgM antibodies is used to support a diagnosis of acute primary infection with EBV. The sample material is human serum or plasma.

It is generally possible to differentiate between the latent and lytic stages of infection with EBV. In the latent phase of the infection, few copies of the viral DNA remain as episomes in the infected cells. These are replicated during cell division and thus passed on to the daughter cells. In the lytic phase on the other hand, all viral genes required for the formation of complete virus particles are activated. Included among the corresponding gene products is the ZEBRA protein (BamHI-Z-encoded Epstein Barr virus replication activator), an immediate early protein (IEA) of EBV. This is a DNA-binding nuclear protein that activates other genes of the lytic phase; its expression precedes the synthesis of other molecules of the lytic phase.

The target antigens of the Anti-EBV (ZEBRA) IgM test are IgM-specific peptides of the ZEBRA protein. The IgM antibodies it detects are found exclusively during the acute primary phase and are early markers of an EBV infection.

 


Technical Data

  • Alegria®


 
Tests   24 Alegria® Test Strips
     
 
Productnumber   ORG 910
     
Evaluation   quantitative
     
Calculation range   0-200 U/ml
     
Cut-off   20-25 U/ml
     
Sensitivity   6.9 U/ml
     
Calibration   arbitrary
     
Substrate   TMB
     
Antigens   ZEBRA peptide

Accessories

• Microplate reader capable of endpoint measurements at 450nm (optional: reference filter at 620nm)

• Data reduction software

• Vortex mixer

• Multichannel dispenser or repeatable pipette for 100µl

 


Downloads

Anti-EBV (ZEBRA) lgM Instructions english

Anti-EBV (ZEBRA) lgM MSDS english


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