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Anti-MCV®

《Specification 》:

Article Number: ORG 548

《Product Introduce 》:

Anti-MCV ® is an ELISA test system for the quantitative measurement of IgG class autoantibodies against mutated citrullinated vimentin (MCV) in human serum or plasma. This product is intended for professional in vitro diagnostic use only.

Features & Functions

 

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The Anti-MCV® ELISA by ORGENTEC detects autoantibodies against mutated citrullinated vimentin (MCV) and is an efficient and reliable serological test for rheumatoid arthritis. Anti-MCV® detects the disease at a very early stage, even in patients who test negative for rheumatoid factor, and to some degree even before the appearance of specific clinical symptoms.

Autoantibodies against mutated citrullinated vimentin are highly specific and extremely sensitive markers for rheumatoid arthritis (specificity 97 %, sensitivity > 82 %). Anti-MCV® autoantibodies are an indicator of advanced injury to the joints and aggressive progression of the disease. In contrast to the detection of antibodies against synthetic cyclic citrullinated peptides, changes in the anti-MCV concentration correspond to changes of clinical parameters. As well as allowing for an unambiguous diagnosis, the Anti-MCV® ELISA thus also makes it possible to monitor therapeutic progress.

For point-of-care diagnosis, rheumachec® provides a rapid blood test that detects both anti-MCV autoantibodies and rheumatoid factor. 

 


Technical Data

  • ELISA

 

 
Tests   12 x 8 determinations
     
 
Productnumber   ORG 548
     
Calculation   quantitative
     
Range   0-1000 U/ml
     
Cut-off   20 U/ml
     
Sensitivity   1 U/ml
     
Calibration   arbitrary
     
Substrate   TMB
     
Antigens   MCV (mutated citrullinated vimentin)

 

 

Accessories

• Microplate reader capable of endpoint measurements at 450nm (optional: reference filter at 620nm)

• Data reduction software

• Vortex mixer

• Multichannel dispenser or repeatable pipette for 100µl

 


Downloads

Anti-MCV® Instructions english

Anti-MCV® MSDS english

ACPA-Tests Flyer english

ORGENTEC Diagnostika ELISA Test System Video english


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