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Rheumatoid Arthritis is a chronic systemic disease generally characterized by swelling and pain in the joints and by inflammatory and degenerative processes involving cartilage, synovial membrane or muscle tissue. The onset of this disease is in adults in their thirties and forties. While no specific cure has been found, early therapy helps in halting or minimizing irreversible damage to the joints. For this reason, prompt diagnosis is of importance. A characteristic of rheumatoid arthritis is the presence in the blood and in synovial fluid of a reactive group of proteins collectively known as the Rheumatoid Factors. These are macroglobulins having a molecular weight of about one million. In the opinion of many investigators the RF are antibodies directed against “altered” human gamma globulin. The RF are found in 70-100% of cases of definite rheumatoid arthritis depending on the test procedure used to detect them. Because of this widespread incidence of RF, its demonstration is a useful laboratory criterion for the diagnosis of suspected cases of rheumatoid arthritis. By comparison the occurrence of RF in osteoarthritis or rheumatic fever is less than 2% and 3% respectively. It should be noted that incidence of RF have been reported in a variety of non-rheumatic diseases such as pulmonary tuberculosis, bacterial endocarditis, syphilis, as well as others. A significant incidence of RF in the aged has also been observed. The principle of this test is based on the immunologic reaction between the RF in serum with the corresponding IgG coated onto latex particles resulting in visible agglutination. |
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• Rheumatoid Factor Serology Latex Test Instructions english
1-Step P... |
Rotaviru... |
S. aureu... |
Streptoc... |
Systemic... |
RPR Carb... |
Salmonel... |
Salmonel... |
C-reacti... |
Anti-Str... |
Cryptoco... |
