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Anti-Helicobacter Pylori IgG

《Specification 》:

Article Number: ORG 917G

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Features & Functions

 

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Helicobacter pylori is a Gram-negative, helix-shaped bacterium that colonizes the human stomach. More virulent type I strains are differentiated from the less virulent type II strains. The former have additional pathogenic factors, such as the vacuolating cytotoxin VacA and cytotoxin-associated CagA.

About half of the global human population is infected with H. pylori. The infection is often acquired in early childhood. In most cases, the infection is asymptomatic and remains undetected. However, about 10-15 % of those infected develop severe stomach diseases ranging from gastric ulcers to lymphoma and adenocarcinoma of the stomach. Left untreated, H. pyloriremains in the human stomach throughout an entire lifespan. Eradication is only possible with a combination of special antibiotics.

There are various invasive and non-invasive methods for the detection of 
H. pylori infections. Non-invasive serological analyses are easy to carry out and have high sensitivity and specificity. Antibodies against the bacterial pathogenicity factors, particularly CagA, are statistically more prevalent in serious infections. 

Specific antibodies against H. pylori are detectable by ELISA shortly after infection. The immune response to H. pylori generally begins with the formation of IgM antibodies, followed by an increase in the IgG and IgA antibody titres, which remain over the course of the infection.

 


Technical Data

  • Alegria®


 
Tests   24 Alegria® Test Strips
     
 
Productnumber   ORG 917G
     
Evaluation   quantitative
     
Calculation range   0-200 U/ml
     
Cut-off   20-25 U/ml
     
Sensitivity   2,3 U/ml
     
Calibration   internal
     
Substrate   TMB
     
Antigens   Helicobacter pylori whole-cell lysate and recombinant CagA

Accessories

• Microplate reader capable of endpoint measurements at 450nm (optional: reference filter at 620nm)

• Data reduction software

• Vortex mixer

• Multichannel dispenser or repeatable pipette for 100µl

 


Downloads

Anti-Helicobacter pylori Flyer english

Anti-Helicobacter pylori IgG Instructions english

Anti-Helicobacter pylori IgG MSDS english


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