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Anti-EBV (VCA) IgM

《Specification 》:

Article Number: ORG 901MX

with rheumatoid factor absorbent

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Features & Functions

 

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The Anti-EBV (VCA) IgM ELISA is a quantitative test system for the automated detection of IgM antibodies against the Epstein-Barr virus. Human serum and plasma are used for the test sample. Anti-EBV (VCA) IgM detects antibodies against the viral capsid antigen (VCA), which allows for detection of acute or reactivated infection with Epstein-Barr virus.

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis (kissing disease). Like all herpes viruses, EBV is distributed around the globe and persists throughout the lifetime of its host. EBV plays an important role in the onset of malignant diseases, including Burkitt’s lymphoma, nasopharyngeal carcinoma, and lymphoproliferative syndromes. The virus is transmitted through saliva.

Through detection of the various antibodies, it is possible to determine the stage of the infection as well as the immune status of the patient: In the early stage of the disease, IgM and IgG antibodies against VCA, the viral capsid antigen of the Epstein-Barr virus, are detectable. About three weeks after the onset of symptoms, the maximum concentration of IgM antibodies against the VCA peptide is attained; the highest concentration of VCA IgG antibodies is reached after about six weeks. This high concentration of VCA IgG antibodies remains throughout the life of the patient.

In parallel, six to eight weeks after infection, antibodies against EBNA (Epstein-Barr nuclear antigen) are formed. These are also detectable with the Anti-EBV (EBNA-1) IgG from ORGENTEC Diagnostika.

IgM class rheumatoid factors may lead to false results in tests for the pathogen-specific detection of IgM antibodies. Anti-EBV (VCA) IgM Abs. (ORG 901MX) is equipped with the ORGENTEC rheumatoid factor absorbent. This reagent absorbs any rheumatoid factors present during sample processing in Alegria®, which makes separate preparation of the serum sample unnecessary.

 


Technical Data

  • Alegria®


 
Tests   24 Alegria® Test Strips
     
 
Productnumber   ORG 901MX
     
Evaluation   quantitative
     
Calculation range   0-200 U/ml
     
Cut-off   20-25 U/ml
     
Sensitivity   5.8 U/ml
     
Calibration   arbitrary
     
Substrate   TMB
     
Antigens   p18 peptides (recombinant)

Accessories

• Microplate reader capable of endpoint measurements at 450nm (optional: reference filter at 620nm)

• Data reduction software

• Vortex mixer

• Multichannel dispenser or repeatable pipette for 100µl

 


Downloads

Anti-EBV (VCA) IgM Instructions english

Anti-EBV (VCA) IgM MSDS english


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